![]() ![]() Through a combination of BrdU incorporation studies and confocal imaging, we show that FGF14 is dynamically expressed in DG at various developing states of neural progenitors. Here, we provide evidence for a previously undescribed function of fibroblast growth factor 14 (FGF14), a brain disease-associated factor that controls neuronal excitability and synaptic plasticity, in regulating adult neurogenesis in the dentate gyrus (DG). However, a complete understanding of the molecular elements at the base of adult neurogenesis remains elusive. Growing evidence indicates that adult neurogenesis, the production of mature neurons from progenitor cells in the adult mammalian brain, is linked to the etiology of neurodegenerative and psychiatric disorders.
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